In the COL1A2 gene, located on chromosome 7 (7q21.3), the rs42524 variant [NC_000007.14:g.94413927C>G], found in exon 28 [16,17], has been studied not only in the context of osteoporosis but also in relation to cardiovascular diseases and metabolic disorders [18]. The gene discussed is COL1A2; the disease is metabolic disease.