Man et al. observed similar cytokine patterns in patients with bone tumors and depression—IL-6 and IL-1β levels were elevated and correlated with Hamilton Depression Rating Scale (HAMD-17) scores, while anti-inflammatory cytokines, such as IL-10 and transforming growth factor beta 1 (TGF-β1), were decreased prior to treatment. This evidence concerns the gene IL1B and major depressive disorder.