Other known gene variations that lead to NS are NS3 (609942), KRAS (190070); NS4 (610733), SOS1 (182530); NS5 (611553), RAF1 (164760); NS6 (613224), NRAS (164790); NS7 (613706), BRAF (164757); NS8 (615355), RIT1 (609591); NS9 (616559), SOS2 (601247); NS10 (616564), LZTR1 (600574); NS11 (618499), MRAS (608435), NS12 (618624), RRAS2 (600098), NS13 (619087) and MAPK1 (176948), while the autosomal recessive form of Noonan syndrome is caused by NS2 (605275), LZTR1 (600574), NS14 (619745) and SPRED2 (609292) [5,6,7]. The gene discussed is LZTR1; the disease is Noonan syndrome.