Peptidylarginine deiminase 4 (PAD4) inhibitors, including GSK484 and Cl-amidine, attenuate histone citrullination and NET formation, while in S. aureus endocarditis models, PAD4 inhibition and DNase-I-mediated extracellular DNA degradation significantly reduce vegetation size and bacterial load [104,122]. This evidence concerns the gene PADI4 and endocarditis.