The severity and extent of inflammation are two factors that influence bone metabolism in IBD, impacting the elevation of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukins (IL) IL-1β, IL-6, and IL-17, which exert a detrimental effect on bone tissue [5,6,7]. The gene discussed is TNF; the disease is inflammatory bowel disease.