This study certified that NT-proBNP, a primary marker of myocardial dysfunction and degree of renal damage, and PASP, an indicator of increased LV filling pressures and pulmonary hypertension (PH), were the two persistent independent predictors of all-cause long-term mortality across all the eGFR subgroups. The gene discussed is NPPB; the disease is pulmonary arterial hypertension.