The levels of serum CRP (30.2 vs. 12.9 mg/L, p = 0.031) and fibrinogen (5.08 vs. 4.38 g/L, p = 0.009) in patients with CPFE were significantly higher than those with isolated IPF, with no statistical difference in terms of NLR, PLR, and IL-6. This evidence concerns the gene IL6 and combined pulmonary fibrosis-emphysema syndrome.