Of particular interest are the SNPs within the NOS3 (endothelial nitric oxide synthase), F5 (Leiden factor), TNFSF4 (cytokine pathway), and CDKN2B-AS1 (cell cycle regulation) genes, which may play a key role in the development of vascular dysfunction and hypertension in this pathology (Table S1). The gene discussed is NOS3; the disease is hypertensive disorder.