The importance of SUVmax as a predicting factor in 68Ga -PSMA PET/CT imaging was also proven by Heetman et al. Specifically, researchers created logistic regression models for 386 patients with International Society of Urological Pathology (ISUP) Grade Group (GG)  ≥  2 and GG  ≥  3 prostate cancer, using noninvasive information collected before a biopsy, such as age, prostate-specific antigen density, presence of a PI-RADS 5 lesion, signs of cancer spreading outside the prostate on MRI and SUVmax of the prostate in 68Ga -PSMA PET/CT. This evidence concerns the gene KLK3 and Familial prostate cancer.