This signal was clarified in a prospective analysis of 108 EUS-FNA cyst fluids: among lesions molecularly classified as mucinous, 60% of the GNAS+/KRAS− subgroup carried non-canonical in-frame insertions or deletions in exons 11 or 15 of BRAF (e.g., p.V600_K601delinsE, p.N486_P490del), with variant-allele fractions between 15% and 47%. The gene discussed is GNAS; the disease is cyst.