Endogenous GIP is secreted most potently in response to high lipid meals [16], while GIP infusion enhances adipose tissue blood flow in lean patients [17] and lipid deposition (e.g., reduced plasma non-essential fatty acids (NEFA), increased adipose triglycerides (TG)) in patients with obesity and type 2 diabetes (T2D) [18]. The gene discussed is GIP; the disease is obesity due to melanocortin 4 receptor deficiency.