Given the well-established role of inflammation and immune dysregulation in PD, along with its potential to exacerbate vulnerability to infections and complications, we were motivated to investigate the nutritional and immunological parameters, such as AISI, SII, SIRS, NLR, PLR, LMR, and HALP, as potential predictors of postoperative outcomes in patients undergoing DBS. This evidence concerns the gene NAT10 and systemic inflammatory response syndrome.