Lastly, three SNPs, namely rs6759298, rs12186979, and rs2836883, which affect RN7SL51P, PTGER4, and RPL23AP12, respectively, have been associated with AS susceptibility in GWASs, while they were also used in an RA association study, investigating a possible connection between these SNPs and ACPA+ RA genetic risk score [22,78]. The gene discussed is PTGER4; the disease is rheumatoid arthritis.