Increased concentrations of HAI-1, STMN-1 and TN-C (especially STMN-1 and the combination of HAI-1+STMN-1) in the urine of patients with BC may indicate the appearance of neoplastic changes in the bladder, and thus provide additional prognostic information on the results of treatment and possible disease recurrence. This evidence concerns the gene TNC and breast cancer.