Independent groups have demonstrated that inhibition of multiple IP subunits (e.g., dual LMP2/LMP7 inhibition) was required for the effective suppression of antigen presentation and T cell-mediated inflammation in experimental models of autoimmunity, while selective inhibitors of either LMP7 or LMP2 were ineffective [16,54,55]. This evidence concerns the gene PSMB8 and Autoimmunity.