The high level of estrogen receptors and aromatase expression of estrogen and its production by mesenchymal cells of the orbital adipose tissue could explain the greater probability of invasive lobular carcinoma to metastasize to the orbit and other atypical sites, providing a favorable ground for BC ILC metastatic cells’ growth [22,23,24]. This evidence concerns the gene CYP19A1 and invasive lobular breast carcinoma.