The high level of estrogen receptors and aromatase expression of estrogen and its production by mesenchymal cells of the orbital adipose tissue could explain the greater probability of invasive lobular carcinoma to metastasize to the orbit and other atypical sites, providing a favorable ground for BC ILC metastatic cells’ growth [22,23,24]. The gene discussed is ESR1; the disease is invasive lobular breast carcinoma.