Conversely, variables associated with a potentially worse prognosis included the following: lymph node ratio ((LNR) (HR = 3.99, 95% CI 1.25–12.7, p = 0.032)), preoperative CEA level (HR = 1.001, 95% CI 1.0004–1.0024, p = 0.006), liver metastasis size ≥10 cm (M1 ≥ 10 cm) (HR = 2.34, 95% CI 1.11–4.92, p = 0.044), degree of hepatopathy at diagnosis (moderate/severe) (HR = 2.63, 95% CI 1.63–4.26, p < 0.001), and resected primary tumor and all metastases (CR2) (HR = 1.96, 95% CI 1.03–3.74, p = 0.04). This evidence concerns the gene CEACAM5 and Decreased liver function.