Further research is warranted to clarify the roles of Fusobacteria and Akkermansia in EoCRC, particularly exploring their associations with: (1) clinicopathological features, including tumor location, stage, prognosis; (2) lifestyle factors, such as obesity; and (3) tumor molecular characteristics, notably MMR status, since these remain poorly understood and inconsistently reported. The gene discussed is MRC1; the disease is obesity due to melanocortin 4 receptor deficiency.