A hallmark of the HCC TME is hypoxia, which stabilizes HIFs, particularly HIF-1α—a master transcription factor that upregulates key proangiogenic mediators such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) [61,71,72,73,74,75,76]. This evidence concerns the gene VEGFA and hepatocellular carcinoma.