When a targeted CRISPR-Cas9 genetic screen was performed to identify chromatin vulnerabilities associated with NRF2 activation in mouse lung cancer cells, genes encoding the class I histone deacetylases (HDAC) (Hdac1, Hdac2, and Hdac3) were found to be synthetically lethal with Keap1 loss. The gene discussed is KEAP1; the disease is lung carcinoma.