NRF2 has been shown to influence six key metabolic pathways associated with cancer progression, which are as follows: (1) dysregulated uptake of glucose and amino acids; (2) use of opportunistic modes of nutrient acquisition; (3) use of glycolysis/TCA cycle intermediates for biosynthesis and NADPH production; (4) increased demand for nitrogen; (5) alterations in metabolite-driven gene regulation; and (6) metabolic interactions with the microenvironment [113]. This evidence concerns the gene NFE2L2 and cancer.