NFE2L2 and breast carcinoma: In breast cancer cells, increased NRF2 levels enhanced both proliferation and migration by upregulating key components of the pentose phosphate pathway (e.g., G6PD), including hypoxia-inducible factor 1α (HIF1α) and NOTCH1, with NOTCH signaling inducing breast cancer cell migration by upregulating the EMT [60].