LOX and cancer: Relevant mechanobiological strategies for cancer treatment include targeting proteins necessary for ECM stiffness (e.g., TGF-β, collagen), ECM crosslinking (e.g., Pan LOX, LOX, LOXL2), ECM mechanosensors and mechanotransducers (e.g., integrins, Piezo channels), and nuclear mechanotransduction through interventions including drug treatment, mechanical stretch, and low-intensity pulsed ultrasound (LIPU) [196,197,198].