As a first example, the Accurate Prediction Model of HNSCC Overall Survival Score (APMHO), developed using transcriptional data of six key cancer driver genes (CRLF2, HSP90AA1, MAP2K1, PAFAH1B2, MYCL, and SET) alongside clinical variables like age and tumor stage, demonstrated robust predictive performance and highlighted distinct molecular and immune profiles between high- and low-APMHO groups [40]. Here, CRLF2 is linked to head and neck squamous cell carcinoma.