In PDAC, pancreatic cancer cell-secreted BAG3 activates macrophages via IFITM2-mediated signaling pathways such as PI3K and p38 MAPK phosphorilation, increasing tumor development and metastasis in a way that can be inhibited by a specific anti- BAG3, neutralizing monoclonal antibody [22]. This evidence concerns the gene BAG3 and familial pancreatic carcinoma.