BAG3 and triple-negative breast carcinoma: In ovarian cancer, for example, elevated BAG3 levels are associated with poor prognosis and resistance to treatments like paclitaxel and cisplatin [18], while in triple-negative breast cancer (TNBC), BAG3 overexpression contributes to apoptosis resistance and enhances cytoprotective autophagy, making these cells more resilient to chemotherapeutic agents [19].