As an example, BAG3 expression in glioblastomas increases with tumor grade, and BAG3 silencing by siRNA inhibits cell growth both in vitro and in vivo [10], while elevated BAG3 levels in pancreatic ductal adenocarcinoma (PDAC) [11] and medulloblastoma [21] are associated with shorter patient survival. This evidence concerns the gene BAG3 and pancreatic ductal adenocarcinoma.