IL6 and melanoma: In vitro treatment of a panel of human melanoma cell lines with SRA737 + low dose HU also resulted in increased expression of the pro-inflammatory chemokines CCL2, CCL5, CXCL8, CXCL10, IL6, XCL1, and TNF, and had modest effects on VEGFA and TGFB1 although the magnitude of expression was different for each cell line (Figure 2C).