This study showed that SRA737 + LDHU treatment of melanoma cells that is sufficient to kill a high proportion of cells also upregulates the expression of pro-inflammatory cytokines and chemokines cells, including CCL2, CCL5, CXCL8, CXCL10, IL-6, TNF, and XCL1, and immunosuppressive VEGFA and TGFB1 before significant cell death occurs. Here, TNF is linked to melanoma.