Against NB, small molecule inhibitors with HDAC8 specificity (such as 1-naphthohydroxamic acid, PCI-34051, and 3-benzylamino-benzhydroxamic acid) demonstrated potent effects in vitro and in mice models, causing the induction of cell differentiation and reduction in tumor growth [86,87,88,89]. Here, HDAC8 is linked to neuroblastoma.