RUNX1 and Friedreich ataxia: Within the chromosomes or chromosomal regions involved in CCAs, in addition to the genes commonly associated with MDS and AML in patients with FA, such as MDM4, EVI1, and RUNX1 [23,26], we identified other genes contained in CCAs that may also play a role in the progression to these malignancies, as detailed in Supplementary Table S3.