Liang et al. examined CD25 expression in 88 pediatric ALK+ ALCL patients in a univariate analysis and found that patients with high CD25 ALK+ ALCL tended to have lower 5-year overall survival (OS) compared with those with low CD25 ALK+ ALCL; however, this difference did not reach statistical significance (p = 0.05) [25]. This evidence concerns the gene ALK and anaplastic large cell lymphoma.