NQO1 and familial pancreatic carcinoma: It revealed that the accumulation of p62, related to autophagy dysfunction, and NAD(P)H quinone oxidoreductase 1 (NQO1), an antioxidant defense enzyme that protects cells from oxidative stress by neutralizing harmful free radicals, were observed in pancreatic acinar cells, acinar-ductal metaplasia, and pancreatic cancer cells within the fatty area [14].