DNMT3A and metastatic malignant neoplasm in the lymph nodes: As shown in Table 2, low expression of DNMT3A, low expression of DNMT3B, and locoregional lymph node metastases at presentation (N+-status) were significant significantly associated with disease-specific mortality in univariable Cox regression analysis (p = 0.029, p = 0.047, p = 0.001, respectively).