Similarly, Chen et al. reported that Rb1 treatment reduced IL-1β levels, attenuated cartilage degeneration, and lowered histologic damage scores by suppressing MMP-13 and type X collagen expression in C5.18 cells (rat chondrocyte) and rat osteoarthritis model combining ACLT and medial cruciate ligament transection (MCLT) [110]. This evidence concerns the gene RB1 and osteoarthritis.