TLR4 and hepatocellular carcinoma: The results indicated that GFG-4 has the potential to inhibit the growth of hepatocellular carcinoma by activating the TLR4/NF-κB signaling pathway and regulating gut microbiota (increasing the abundance of norank_f__Muribaculaceae and Bacillus, while decreasing the abundance of lactic acid bacteria) in H22 cell line xenograft tumors in nude mice [15].