Furthermore, water-soluble glycoprotein fractions from the vegetative mycelium of L. edodes have been shown to inhibit the metabolic activity of various human and animal cancer cell lines, including A549 (human lung adenocarcinoma), HeLa (human cervical carcinoma), Hep-2 (laryngeal cancer), SPEV-2 (porcine kidney embryo), and C6 (rat glioma) cells. Here, ART4 is linked to central nervous system cancer.