TGFB1 and Increased circulating aldosterone concentration: Potassium supplementation had a more prominent effect on pulse pressure, which is associated with cardiac remodeling [26,31] and the downregulation of TGF-β1, collagen genes, and other fibrotic markers in the DOCA-UNX, perhaps due to the fibrotic and inflammatory effects of mineralocorticoid excess, when compared with the L-NAME model.