MTOR and cancer: In addition, ISO significantly down-regulated the expression of phosphorylated PI3K (p-PI3K), phosphorylated Akt (p-Akt), and phosphorylated mTOR (p-mTOR) in two types of cancer cells, revealing a potential mechanism of action by which ISO may act as an inhibitor of the PI3K-Akt-mTOR pathway [25].