CYCS and gastric cancer: That finding is consistent with the study of Li et al. who found that ISO treatment of gastric cancer cells (AGS-1 and HGC-27) initiated the activation of the caspase-3 cascade and increased the expression of Bax/Bcl-2 and cytochrome C, and activated caspase-3 cleavage and poly (ADP-ribose) polymerase (PARP)), leading to a reduction in mitochondrial membrane potential and the accumulation of ROS.