Moreover, while cell–cell border delocalization of claudin-1 was documented in the BBB endothelial cells treated with the plasma of the lupus mice as a punctate intracytoplasmic fluorescence pattern, only the cells treated with the plasma of the CLC group exhibited a complete reversal of this redistribution of claudin-1 (Figure 6). This evidence concerns the gene CLDN1 and systemic lupus erythematosus.