CALCA and acne: The Zn-de-Model group exhibited higher levels of these cytokines than the Model group, with increases of 51.74% for TNF-α, 11.91% for IL-1β, 118.06% for IL-17A, 19.64% for MMP9, and 17.05% for CXCL1/KC, indicating that Zn deficiency leads to more severe skin inflammation in acne-like mice.