Since inflammation and oxidative stress are the main causes of fibrosis [30], combined with Figure 3a and the mRNA expression detection of fibrosis-related factors (Collagen Type I Alpha 1 Chain (COL1A1), transforming growth factor beta (TGF-β), yes-associated protein (YAP), and Collagen Type III Alpha 1 Chain (COL3A1)) (Figure 3m–p), it shows that OFI-F plays a certain role in mitigating fibrosis development in DN mice by attenuating inflammatory responses and enhancing antioxidant defense mechanisms, which are associated with its improvement of renal injury. This evidence concerns the gene COL3A1 and liver dysplastic nodule.