TGFB1 and liver dysplastic nodule: Since inflammation and oxidative stress are the main causes of fibrosis [30], combined with Figure 3a and the mRNA expression detection of fibrosis-related factors (Collagen Type I Alpha 1 Chain (COL1A1), transforming growth factor beta (TGF-β), yes-associated protein (YAP), and Collagen Type III Alpha 1 Chain (COL3A1)) (Figure 3m–p), it shows that OFI-F plays a certain role in mitigating fibrosis development in DN mice by attenuating inflammatory responses and enhancing antioxidant defense mechanisms, which are associated with its improvement of renal injury.