For instance, in a study of core binding factor AML (CBF-AML), including recurrent genetic translocations t(8;21)(q22;q22) involving RUNX1-RUNX1T1 and inv(16)(p13q22) involving CBFB-MYH11 [5], multivariate analyses of that study showed that KDM6A mutation was associated with OS (P < 0.001) but not with EFS (P = 0.095) in the RUNX1::RUNX1T1 cohort. The gene discussed is RUNX1T1; the disease is acute myeloid leukemia.