RUNX1 and acute myeloid leukemia: For instance, in a study of core binding factor AML (CBF-AML), including recurrent genetic translocations t(8;21)(q22;q22) involving RUNX1-RUNX1T1 and inv(16)(p13q22) involving CBFB-MYH11 [5], multivariate analyses of that study showed that KDM6A mutation was associated with OS (P < 0.001) but not with EFS (P = 0.095) in the RUNX1::RUNX1T1 cohort.