While Zhuang et al. focused on longer-term dementia risk in a general aging population using seven protein biomarkers (e.g., APOE, NRCAM, CRP), our study complements this work by targeting a shorter prediction window (one year) and integrating functional data from gait and neuropsychological assessments, which may be more applicable in early-stage, clinically ambiguous cases such as MCR [10]. The gene discussed is CRP; the disease is dementia.