Core biomarkers—including cerebrospinal fluid (CSF) amyloid-beta 42 (Aβ42), amyloid positron emission tomography (amyloid PET), cerebrospinal fluid Tau protein (CSF Tau), and magnetic resonance imaging with fluorodeoxyglucose positron emission tomography (MRI FDG-PET)—were analyzed simultaneously to compute the cognitive impairment (CI) score of instances, dynamically adjusted for age. Here, MAPT is linked to Cognitive impairment.