T regulatory cells (ICOS+-CTLA4+ T-regs) and CXCR4+CD38-CD8+ cells, as well as neutrophils, DCs, and tumor-associated macrophages expressing PD-L1+ (PD-1+TAMs), CAFs, and other cells have been identified in the TiME 2 subtype [122,126]. The gene discussed is PDCD1; the disease is neoplasm.