This cascade promotes the expression of Mucin 5AC (MUC5AC), Periostin, and C-C Motif Chemokine Ligand 26 (CCL26), contributing to epithelial barrier destruction via ferroptosis, sub-epithelial fibrosis, eosinophil migration, goblet cell differentiation, and the activation of mast cells, immature dendritic cells, and T-cells hallmark features of asthma [19,20,21,22,23] (Figure 1). This evidence concerns the gene MUC5AC and asthma.