Furthermore, direct biomarkers (e.g., IL-6) or other evidence excluding bacterial co-infections has not been investigated, our article reflects the real-word experience of a paediatric emergency department, in which IL-6 dosage is inaccessible, haemoculture is not routinely asked for, excepting when suspecting invasive bacterial infections, and only WBC, CRP, and PCT are available to help clinicians distinguish between viral and bacterial infections. Here, IL6 is linked to bacterial infectious disease.