Systemic inflammation in COPD is particularly characterized by increased TNFα, IL-1β, IL-6, IL-8, and IFNγ serum levels (MacNee 2013; Moermans et al. 2011; Sinden et al., 2010; Zou et al. 2017). This evidence concerns the gene CXCL8 and chronic obstructive pulmonary disease.