Of the ten regions identified for risk, we found evidence that mQTLs in three regions (PANDAR/LAP3P2 in chromosome 6, POU2AF2 /COLCA1/ POU2AF3 in chromosome 11 and CABLES2/LAMA5 in chromosome 20) colocalise with GWAS signals suggesting that DNA methylation might be involved in CRC susceptibility. The gene discussed is POU2AF2; the disease is colorectal carcinoma.