In the absence of RavZ, autophagy components such as GABARAPL1, ATG16L1, and FIP200 were enriched following infection with the ΔR strain, whereas STX17 interacted with several lysosomal proteins, including cathepsins (CTSB and CTSD), LAMP proteins, the mTOR complex (LAMTOR3, LAMTOR5 and TSC2) and the lysosomal V-ATPase (ATP6V0A1, ATP6V0A2, ATPV0C and ATP6V1H) following infection with the ΔRΔS strain (Fig. 4E,F). The gene discussed is LAMTOR3; the disease is infection.