CIAPIN1 acts as a cell death resistance factor by inhibiting apoptosis induced by apoptotic signaling.51,52 It forms a complex that interferes with mitochondrial apoptotic processing through intermolecular cooperation with cofactors such as Tah18 or TXNL2.52 The role of CIAPIN1 in RA or ACs has not been extensively studied. This evidence concerns the gene CIAPIN1 and rheumatoid arthritis.