Strikingly, the enhanced pro-inflammatory response in Nedd9-/- macrophages was accompanied by significantly reduced bacterial burden of ST in Nedd9-/- compared to Nedd9wt/wt mBMDMs, shown as a higher fold reduction of bacterial burden, implying that loss of Nedd9 enhances the clearance of bacterial infection (Fig. 3G). The gene discussed is NEDD9; the disease is bacterial infectious disease.