We demonstrated PARP1 overexpression in BCCs and PARPi-FL’s ability to passively permeate intact skin within 10–30 min of topical application and improve the diagnostic accuracy of BCC in ex vivo human tissues compared with reflectance confocal microscopy, demonstrating that 10-μM PARPi-FL was optimal for permeability (18). This evidence concerns the gene PARP1 and skin basal cell carcinoma.