Furthermore, mesenchymal stem cells’ extracellular vesicle component, miRNA-148a-5p, alters the polarization status of macrophages, decreases the number of inflammatory cells, and ameliorates liver fibrosis via downregulating KLF6 expression and influencing STAT3 phosphorylation in the JAK/STAT pathway [25]. This evidence concerns the gene STAT3 and Hepatic fibrosis.