Verapamil is an antagonist of voltage-gated calcium channels (CaV), inhibiting CaV1.2 with IC50 values from 0.3 to 5 μM, and CaV1.1 with IC50 values around 10 μM (Alexander et al, 2021), and is used for the treatment of cardiovascular diseases. Here, CACNA1C is linked to cardiovascular disorder.