CCN2 and infection: Similarly, genes associated with the epithelial type 2 response (Muc2 and Il33) (Hammad and Lambrecht, 2015), scavenger receptor signaling (Cd36) (Hammad and Lambrecht, 2015), and tissue fibrosis and wound repair (Ctgf) (Gieseck et al., 2018) were all upregulated by day 8 but returned to noninfected expression levels by day 16 after infection (Fig. 4 F), though goblet cell counts remained somewhat elevated (Fig. S4, E and F).